ACOT2 (acyl-CoA thioesterase 2)

2014-11-01  

Identity

HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
CTE-IA,CTE1A,MTE1,PTE2,PTE2A,ZAP128

Other Information

Locus ID:

NCBI: 10965
MIM: 609972
HGNC: 18431
Ensembl: ENSG00000119673

Variants:

dbSNP: 10965
ClinVar: 10965
TCGA: ENSG00000119673
COSMIC: ACOT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119673ENST00000238651P49753
ENSG00000119673ENST00000538782F6VI00
ENSG00000119673ENST00000613168A0A087WT95
ENSG00000119673ENST00000622407A0A087X0W7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Fatty acid elongationKEGGko00062
Biosynthesis of unsaturated fatty acidsKEGGko01040
Fatty acid elongationKEGGhsa00062
Biosynthesis of unsaturated fatty acidsKEGGhsa01040
Metabolic pathwaysKEGGhsa01100
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
352158352022Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.2
361931672022High Expression of ACOT2 Predicts Worse Overall Survival and Abnormal Lipid Metabolism: A Potential Target for Acute Myeloid Leukemia.2
352158352022Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.2
361931672022High Expression of ACOT2 Predicts Worse Overall Survival and Abnormal Lipid Metabolism: A Potential Target for Acute Myeloid Leukemia.2
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
194973002009Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2).7
194973002009Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2).7

Citation

Dessen P

ACOT2 (acyl-CoA thioesterase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60090/tumors-explorer/haematological-explorer/css/template-nav.css