ADO (2-aminoethanethiol dioxygenase)

2014-11-01 Affiliation

Identity

HGNC

ADO

LOCATION

10q21.3

LOCUSID

84890

ALIAS

C10orf22

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84890
MIM: 611392
HGNC: 23506
Ensembl: ENSG00000181915

Variants:

dbSNP: 84890
ClinVar: 84890
TCGA: ENSG00000181915
COSMIC: ADO

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000181915	ENST00000373783	Q96SZ5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Taurine and hypotaurine metabolism	KEGG	ko00430
Taurine and hypotaurine metabolism	KEGG	hsa00430
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Sulfur amino acid metabolism	REACTOME	R-HSA-1614635
Degradation of cysteine and homocysteine	REACTOME	R-HSA-1614558

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA444552	Hypertension	Disease	ClinicalAnnotation	associated		PD	31327267
PA449899	hydrochlorothiazide	Chemical	ClinicalAnnotation	associated		PD	31327267

References

Pubmed ID	Year	Title	Citations
34508780	2021	Crystal structure of human cysteamine dioxygenase provides a structural rationale for its function as an oxygen sensor.	9
34508780	2021	Crystal structure of human cysteamine dioxygenase provides a structural rationale for its function as an oxygen sensor.	9
32437414	2020	Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with susceptibility to Vogt-Koyanagi-Harada disease in Japanese population.	4
32601061	2020	Characterization of the nonheme iron center of cysteamine dioxygenase and its interaction with substrates.	13
32437414	2020	Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with susceptibility to Vogt-Koyanagi-Harada disease in Japanese population.	4
32601061	2020	Characterization of the nonheme iron center of cysteamine dioxygenase and its interaction with substrates.	13
31273118	2019	Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.	87
31273118	2019	Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.	87
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	20
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	20
17581819	2007	Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.	59
17581819	2007	Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.	59

Citation

Dessen P

ADO (2-aminoethanethiol dioxygenase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60167