ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2)

2014-11-01  

Identity

HGNC
LOCATION
4p14
LOCUSID
ALIAS
CENTD1,PARX
FUSION GENES

Other Information

Locus ID:

NCBI: 116984
MIM: 606645
HGNC: 16924
Ensembl: ENSG00000047365

Variants:

dbSNP: 116984
ClinVar: 116984
TCGA: ENSG00000047365
COSMIC: ARAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000047365ENST00000303965Q8WZ64
ENSG00000047365ENST00000506189D6RAD6
ENSG00000047365ENST00000511416D6RC39
ENSG00000047365ENST00000618163A0A0C4DGW1

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
358426672022The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition.4
358426672022The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition.4
301443592018ARAP2 inhibits Akt independently of its effects on focal adhesions.7
301443592018ARAP2 inhibits Akt independently of its effects on focal adhesions.7
252252932014The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic.30
252252932014The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic.30
232951822013ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology.20
232951822013ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology.20
208232052010Critical role for the host GTPase-activating protein ARAP2 in InlB-mediated entry of Listeria monocytogenes.12
208232052010Critical role for the host GTPase-activating protein ARAP2 in InlB-mediated entry of Listeria monocytogenes.12
170771262006ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP.39
170771262006ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP.39

Citation

Dessen P

ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60453/js/case-report-explorer/