ARFGAP1 (ADP ribosylation factor GTPase activating protein 1)

2014-11-01 Affiliation

Identity

HGNC

ARFGAP1

LOCATION

20q13.33

LOCUSID

55738

ALIAS

ARF1GAP,HRIHFB2281

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55738
MIM: 608377
HGNC: 15852
Ensembl: ENSG00000101199

Variants:

dbSNP: 55738
ClinVar: 55738
TCGA: ENSG00000101199
COSMIC: ARFGAP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000101199	ENST00000353546	Q8N6T3
ENSG00000101199	ENST00000370275	Q8N6T3
ENSG00000101199	ENST00000370283	Q8N6T3
ENSG00000101199	ENST00000518601	E5RHT6
ENSG00000101199	ENST00000519273	Q8N6T3
ENSG00000101199	ENST00000519604	Q8N6T3
ENSG00000101199	ENST00000520485	E5RGL6
ENSG00000101199	ENST00000522403	E5RHC5
ENSG00000101199	ENST00000523114	E5RIU2
ENSG00000101199	ENST00000523460	E5RHH7
ENSG00000101199	ENST00000547204	F8VWH9
ENSG00000101199	ENST00000549047	F8W1U7
ENSG00000101199	ENST00000549076	H0YIQ0
ENSG00000101199	ENST00000550188	F8VWB3

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
ER to Golgi Anterograde Transport	REACTOME	R-HSA-199977
Unfolded Protein Response (UPR)	REACTOME	R-HSA-381119
IRE1alpha activates chaperones	REACTOME	R-HSA-381070
XBP1(S) activates chaperone genes	REACTOME	R-HSA-381038
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
COPI-mediated anterograde transport	REACTOME	R-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Golgi-to-ER retrograde transport	REACTOME	R-HSA-8856688
COPI-dependent Golgi-to-ER retrograde traffic	REACTOME	R-HSA-6811434
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37566088	2023	C9orf72 Toxic Species Affect ArfGAP-1 Function.	0
37566088	2023	C9orf72 Toxic Species Affect ArfGAP-1 Function.	0
33715220	2021	ArfGAP1 acts as a GTPase-activating protein for human ADP-ribosylation factor-like 1 protein.	2
33988249	2021	ArfGAP1 inhibits mTORC1 lysosomal localization and activation.	15
33715220	2021	ArfGAP1 acts as a GTPase-activating protein for human ADP-ribosylation factor-like 1 protein.	2
33988249	2021	ArfGAP1 inhibits mTORC1 lysosomal localization and activation.	15
29141986	2018	ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton.	10
29141986	2018	ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton.	10
24623438	2014	Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.	23
25397679	2014	ARFGAP1 is dynamically associated with lipid droplets in hepatocytes.	8
24623438	2014	Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.	23
25397679	2014	ARFGAP1 is dynamically associated with lipid droplets in hepatocytes.	8
22423108	2012	ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2.	65
22423108	2012	ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2.	65
21499258	2011	ARFGAP1 promotes AP-2-dependent endocytosis.	26

Citation

Dessen P

ARFGAP1 (ADP ribosylation factor GTPase activating protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60455