ASB8 (ankyrin repeat and SOCS box containing 8)

2014-11-01  

Identity

HGNC
ASB8
LOCATION
12q13.11
LOCUSID
140461
ALIAS
PP14212
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 140461
MIM: 615053
HGNC: 17183
Ensembl: ENSG00000177981

Variants:

dbSNP: 140461
ClinVar: 140461
TCGA: ENSG00000177981
COSMIC: ASB8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177981ENST00000317697Q9H765
ENSG00000177981ENST00000535055F5GYF0
ENSG00000177981ENST00000535988F5H5S9
ENSG00000177981ENST00000536071F5H772
ENSG00000177981ENST00000536549Q9H765
ENSG00000177981ENST00000536953F5GYF0
ENSG00000177981ENST00000539464F5H243
ENSG00000177981ENST00000539503F5GZZ3
ENSG00000177981ENST00000539528F5GYF0
ENSG00000177981ENST00000539865F5H023
ENSG00000177981ENST00000540143F5H243
ENSG00000177981ENST00000540212F5H7B4
ENSG00000177981ENST00000540782F5H5S9
ENSG00000177981ENST00000545791F5H6A7
ENSG00000177981ENST00000548228F8VS92
ENSG00000177981ENST00000629941F5H243

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
322989232020E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis.11
322989232020E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis.11
125599692003Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family.13
125599692003Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family.13

Citation

Dessen P

ASB8 (ankyrin repeat and SOCS box containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60564/deep-insight-explorer/cancer-prone-explorer/js/lib/popper.js