BDP1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB)

2014-11-01  

Identity

HGNC
BDP1
LOCATION
5q13.2
LOCUSID
55814
ALIAS
DFNB112,HSA238520,TAF3B1,TFC5,TFIIIB,TFIIIB150,TFIIIB90,TFNR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55814
MIM: 607012
HGNC: 13652
Ensembl: ENSG00000145734

Variants:

dbSNP: 55814
ClinVar: 55814
TCGA: ENSG00000145734
COSMIC: BDP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145734ENST00000358731A6H8Y1
ENSG00000145734ENST00000380675A0A0A0MRX7
ENSG00000145734ENST00000514903H7C5U4
ENSG00000145734ENST00000525844H0YCV8

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 PromoterREACTOMER-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 PromoterREACTOMER-HSA-76066
RNA Polymerase III Transcription Initiation From Type 3 PromoterREACTOMER-HSA-76071

References

Pubmed IDYearTitleCitations
325040032020DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability.15
328539452020Somatic mutations of cancer-related genes PELP1 and BDP1 in colorectal cancers.5
325040032020DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability.15
328539452020Somatic mutations of cancer-related genes PELP1 and BDP1 in colorectal cancers.5
287438842017Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.23
287438842017Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.23
243124682013Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.23
243124682013Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.23
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
183910232008PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex.66
183910232008PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex.66
174990432007Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.79
174990432007Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.79
150965012004Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB", is an essential component of human TFIIIC1 activity.12

Citation

Dessen P

BDP1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60731