AKR7A2 (aldo-keto reductase family 7 member A2)

2003-02-01  

Identity

HGNC
AKR7A2
LOCATION
1p36.13
LOCUSID
8574
ALIAS
AFAR,AFAR1,AFB1-AR1,AKR7

Other Information

Locus ID:

NCBI: 8574
MIM: 603418
HGNC: 389
Ensembl: ENSG00000053371

Variants:

dbSNP: 8574
ClinVar: 8574
TCGA: ENSG00000053371
COSMIC: AKR7A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000053371ENST00000235835O43488
ENSG00000053371ENST00000235835V9HWA2
ENSG00000053371ENST00000330072H3BLU7
ENSG00000053371ENST00000481966H7C4Q7
ENSG00000053371ENST00000489286H7C5H7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449212daunorubicinChemicalVariantAnnotationassociatedPK20837989
PA449412doxorubicinChemicalVariantAnnotationassociatedPK20837989

References

Pubmed IDYearTitleCitations
308179762019Insights into the transcriptional regulation of the anthracycline reductase AKR7A2 in human cardiomyocytes.2
308179762019Insights into the transcriptional regulation of the anthracycline reductase AKR7A2 in human cardiomyocytes.2
285366272016The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner.2
285366272016The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner.2
250276722015GST-M1 is transcribed moreso than AKR7A2 in AFB₁-exposed human monocytes and lymphocytes.4
254515872015Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2.9
250276722015GST-M1 is transcribed moreso than AKR7A2 in AFB₁-exposed human monocytes and lymphocytes.4
254515872015Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2.9
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
210443672010An integrative method for scoring candidate genes from association studies: application to warfarin dosing.11
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
210443672010An integrative method for scoring candidate genes from association studies: application to warfarin dosing.11
190774592009Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma.29
190774592009Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma.29
187528862008Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells.3

Citation

Dessen P

AKR7A2 (aldo-keto reductase family 7 member A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/613