CALCOCO2 (calcium binding and coiled-coil domain 2)

2014-11-01  

Identity

HGNC
CALCOCO2
LOCATION
17q21.32
LOCUSID
10241
ALIAS
NDP52
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10241
MIM: 604587
HGNC: 29912
Ensembl: ENSG00000136436

Variants:

dbSNP: 10241
ClinVar: 10241
TCGA: ENSG00000136436
COSMIC: CALCOCO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136436ENST00000258947Q13137
ENSG00000136436ENST00000416445Q13137
ENSG00000136436ENST00000448105Q13137
ENSG00000136436ENST00000502761D6RF70
ENSG00000136436ENST00000505071D6RBI4
ENSG00000136436ENST00000507076D6RBF9
ENSG00000136436ENST00000507306H0Y9G3
ENSG00000136436ENST00000508679Q13137
ENSG00000136436ENST00000509415D6RJE7
ENSG00000136436ENST00000509507Q13137
ENSG00000136436ENST00000509784H0YBP4
ENSG00000136436ENST00000513119D6REB0
ENSG00000136436ENST00000570513I3L493
ENSG00000136436ENST00000576582I3L4E1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379425852024NDP52 SUMOylation contributes to low-dose X-rays-induced cardiac hypertrophy through PINK1/Parkin-mediated mitophagy via MUL1/SUMO2 signalling.1
379425852024NDP52 SUMOylation contributes to low-dose X-rays-induced cardiac hypertrophy through PINK1/Parkin-mediated mitophagy via MUL1/SUMO2 signalling.1
365149532023NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy.13
377775492023Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.3
365149532023NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy.13
377775492023Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.3
354066962022Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN.3
354066962022Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN.3
337233722021Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy.9
338153862021Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.1
337233722021Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy.9
338153862021Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.1
327730362020The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment.33
327730362020The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment.33
301544462019CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation.40

Citation

Dessen P

CALCOCO2 (calcium binding and coiled-coil domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61386