CCDC65 (coiled-coil domain containing 65)

2014-11-01  

Identity

HGNC
CCDC65
LOCATION
12q13.12
LOCUSID
85478
ALIAS
CFAP250,DRC2,FAP250,NYD-SP28

Other Information

Locus ID:

NCBI: 85478
MIM: 611088
HGNC: 29937
Ensembl: ENSG00000139537

Variants:

dbSNP: 85478
ClinVar: 85478
TCGA: ENSG00000139537
COSMIC: CCDC65

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139537ENST00000266984Q8IXS2
ENSG00000139537ENST00000320516Q8IXS2
ENSG00000139537ENST00000547861F8W0R6
ENSG00000139537ENST00000552942F8VR42

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
379752352024CCDC65, encoding a component of the axonemal Nexin-Dynein regulatory complex, is required for sperm flagellum structure in humans.1
379752352024CCDC65, encoding a component of the axonemal Nexin-Dynein regulatory complex, is required for sperm flagellum structure in humans.1
343359832021CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer.22
343359832021CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer.22
239910852013CCDC65 mutation causes primary ciliary dyskinesia with normal ultrastructure and hyperkinetic cilia.61
239910852013CCDC65 mutation causes primary ciliary dyskinesia with normal ultrastructure and hyperkinetic cilia.61
170890172006Cloning and characterization of a novel sperm tail protein, NYD-SP28.10
170890172006Cloning and characterization of a novel sperm tail protein, NYD-SP28.10

Citation

Dessen P

CCDC65 (coiled-coil domain containing 65)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61558/cancer-prone-explorer/js/lib/gene-explorer/