CD300C (CD300c molecule)

2014-11-01  

Identity

HGNC
CD300C
LOCATION
17q25.1
LOCUSID
10871
ALIAS
CLM-6,CMRF-35,CMRF-35A,CMRF35,CMRF35-A1,CMRF35A,CMRF35A1,IGSF16,LIR

Other Information

Locus ID:

NCBI: 10871
MIM: 606786
HGNC: 19320
Ensembl: ENSG00000167850

Variants:

dbSNP: 10871
ClinVar: 10871
TCGA: ENSG00000167850
COSMIC: CD300C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167850ENST00000330793Q08708

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
299065282019CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy.9
299065282019CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy.9
304984972018A CD300c-Fc Fusion Protein Inhibits T Cell Immunity.7
304984972018A CD300c-Fc Fusion Protein Inhibits T Cell Immunity.7
270403282016CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.15
270403282016CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.15
233721572013Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.17
235715072013CD300c is an activating receptor expressed on human monocytes.13
233721572013Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.17
235715072013CD300c is an activating receptor expressed on human monocytes.13
220469702011Differential expression of CD300a/c on human TH1 and TH17 cells.12
220469702011Differential expression of CD300a/c on human TH1 and TH17 cells.12
206569212010Expression and function of CD300 in NK cells.35
206569212010Expression and function of CD300 in NK cells.35
185352062008CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands.36

Citation

Dessen P

CD300C (CD300c molecule)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61619/meetings/js/lib/gene-fusions-explorer/