CLEC4E (C-type lectin domain family 4 member E)

2014-11-01  

Identity

HGNC
CLEC4E
LOCATION
12p13.31
LOCUSID
26253
ALIAS
CLECSF9,MINCLE

Other Information

Locus ID:

NCBI: 26253
MIM: 609962
HGNC: 14555
Ensembl: ENSG00000166523

Variants:

dbSNP: 26253
ClinVar: 26253
TCGA: ENSG00000166523
COSMIC: CLEC4E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166523ENST00000299663Q9ULY5
ENSG00000166523ENST00000446457F8WFA1
ENSG00000166523ENST00000450725F8WFA1
ENSG00000166523ENST00000537698H0YGH9
ENSG00000166523ENST00000545274F5H5X7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
343761762021A case-control study on correlation between the single nucleotide polymorphism of CLEC4E and the susceptibility to tuberculosis among Han people in Western China.0
343761762021A case-control study on correlation between the single nucleotide polymorphism of CLEC4E and the susceptibility to tuberculosis among Han people in Western China.0
318528492020Molecular mechanism of obesity-induced adipose tissue inflammation; the role of Mincle in adipose tissue fibrosis and ectopic lipid accumulation.7
321529422020Immune Recognition of Pathogen-Derived Glycolipids Through Mincle.3
329712502020CLEC4E (Mincle) genetic variation associates with pulmonary tuberculosis in Guinea-Bissau (West Africa).4
318528492020Molecular mechanism of obesity-induced adipose tissue inflammation; the role of Mincle in adipose tissue fibrosis and ectopic lipid accumulation.7
321529422020Immune Recognition of Pathogen-Derived Glycolipids Through Mincle.3
329712502020CLEC4E (Mincle) genetic variation associates with pulmonary tuberculosis in Guinea-Bissau (West Africa).4
307932982019Expression and function of macrophage-inducible C-type lectin (Mincle) in inflammation driven parturition in fetal membranes and myometrium.5
310754102019Association between CLEC4E gene polymorphism of mincle and pulmonary tuberculosis infection in a northern Chinese population.7
307932982019Expression and function of macrophage-inducible C-type lectin (Mincle) in inflammation driven parturition in fetal membranes and myometrium.5
310754102019Association between CLEC4E gene polymorphism of mincle and pulmonary tuberculosis infection in a northern Chinese population.7
280052672017Human gingiva transcriptome during wound healing.14
281415952017The role of Mincle in innate immune to fungal keratitis.9
280052672017Human gingiva transcriptome during wound healing.14

Citation

Dessen P

CLEC4E (C-type lectin domain family 4 member E)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61876