CMPK2 (cytidine/uridine monophosphate kinase 2)

2014-11-01  

Identity

HGNC
CMPK2
LOCATION
2p25.2
LOCUSID
129607
ALIAS
NDK,TMPK2,TYKi,UMP-CMPK2

Other Information

Locus ID:

NCBI: 129607
MIM: 611787
HGNC: 27015
Ensembl: ENSG00000134326

Variants:

dbSNP: 129607
ClinVar: 129607
TCGA: ENSG00000134326
COSMIC: CMPK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134326ENST00000256722Q5EBM0
ENSG00000134326ENST00000404168Q5EBM0
ENSG00000134326ENST00000458098Q5EBM0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387017812024Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke.1
387017812024Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke.1
370750762023CMPK2 restricts Zika virus replication by inhibiting viral translation.4
370750762023CMPK2 restricts Zika virus replication by inhibiting viral translation.4
364518212022The mitochondrial gene-CMPK2 functions as a rheostat for macrophage homeostasis.2
364518212022The mitochondrial gene-CMPK2 functions as a rheostat for macrophage homeostasis.2
338749832021Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE.13
338749832021Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE.13
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
179999542008Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.56
184983542008Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation.20
179999542008Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.56
184983542008Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation.20

Citation

Dessen P

CMPK2 (cytidine/uridine monophosphate kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61922/tumors-explorer/js/lib/case-report-explorer/