COG2 (component of oligomeric golgi complex 2)

2014-11-01 Affiliation

Identity

HGNC

COG2

LOCATION

1q42.2

LOCUSID

22796

ALIAS

CDG2Q,LDLC

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 22796
MIM: 606974
HGNC: 6546
Ensembl: ENSG00000135775

Variants:

dbSNP: 22796
ClinVar: 22796
TCGA: ENSG00000135775
COSMIC: COG2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135775	ENST00000366668	Q14746
ENSG00000135775	ENST00000366669	Q14746
ENSG00000135775	ENST00000366669	B1ALW7
ENSG00000135775	ENST00000468893	V9GY21
ENSG00000135775	ENST00000534989	B7Z2Y2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
ER to Golgi Anterograde Transport	REACTOME	R-HSA-199977
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
COPI-mediated anterograde transport	REACTOME	R-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Retrograde transport at the Trans-Golgi-Network	REACTOME	R-HSA-6811440
Intra-Golgi traffic	REACTOME	R-HSA-6811438

References

Pubmed ID	Year	Title	Citations
24784932	2015	Mutations in COG2 encoding a subunit of the conserved oligomeric golgi complex cause a congenital disorder of glycosylation.	25
24784932	2015	Mutations in COG2 encoding a subunit of the conserved oligomeric golgi complex cause a congenital disorder of glycosylation.	25
19023099	2009	Gene variants associated with ischemic stroke: the cardiovascular health study.	20
19105203	2009	An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.	18
19023099	2009	Gene variants associated with ischemic stroke: the cardiovascular health study.	20
19105203	2009	An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.	18
17975119	2008	Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.	77
17975119	2008	Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.	77
17274799	2007	The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.	45
17274799	2007	The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.	45

Citation

Dessen P

COG2 (component of oligomeric golgi complex 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61976