COLEC11 (collectin subfamily member 11)

2014-11-01  

Identity

HGNC
COLEC11
LOCATION
2p25.3
LOCUSID
78989
ALIAS
3MC2,CL-11,CL-K1-I,CL-K1-II,CL-K1-IIa,CL-K1-IIb,CLK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 78989
MIM: 612502
HGNC: 17213
Ensembl: ENSG00000118004

Variants:

dbSNP: 78989
ClinVar: 78989
TCGA: ENSG00000118004
COSMIC: COLEC11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118004ENST00000236693Q9BWP8
ENSG00000118004ENST00000349077Q9BWP8
ENSG00000118004ENST00000382062Q9BWP8
ENSG00000118004ENST00000402794Q9BWP8
ENSG00000118004ENST00000402922Q9BWP8
ENSG00000118004ENST00000403096Q9BWP8
ENSG00000118004ENST00000404205Q9BWP8
ENSG00000118004ENST00000416132F8WB29
ENSG00000118004ENST00000418971Q9BWP8
ENSG00000118004ENST00000438814C9JWT5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class A ReceptorsREACTOMER-HSA-3000480

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368835672023Collectin-11 promotes cancer cell proliferation and tumor growth.4
368835672023Collectin-11 promotes cancer cell proliferation and tumor growth.4
346156572021Collectin11 and Complement Activation in IgA Nephropathy.8
346156572021Collectin11 and Complement Activation in IgA Nephropathy.8
320417822020C1q/TNF-Related Protein 6 Is a Pattern Recognition Molecule That Recruits Collectin-11 from the Complement System to Ligands.11
320451042020Importance of glycosylation in the interaction of Tamm-Horsfall protein with collectin-11 and acute kidney injury.6
327519292020Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes with 3MC Syndrome.10
320417822020C1q/TNF-Related Protein 6 Is a Pattern Recognition Molecule That Recruits Collectin-11 from the Complement System to Ligands.11
320451042020Importance of glycosylation in the interaction of Tamm-Horsfall protein with collectin-11 and acute kidney injury.6
327519292020Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes with 3MC Syndrome.10
309952222019Human collectin-11 (COLEC11) and its synergic genetic interaction with MASP2 are associated with the pathophysiology of Chagas Disease.5
309952222019Human collectin-11 (COLEC11) and its synergic genetic interaction with MASP2 are associated with the pathophysiology of Chagas Disease.5
301085872018CL-L1 and CL-K1 Exhibit Widespread Tissue Distribution With High and Co-Localized Expression in Secretory Epithelia and Mucosa.14
302378002018Collectin-11 (CL-11) Is a Major Sentinel at Epithelial Surfaces and Key Pattern Recognition Molecule in Complement-Mediated Ischaemic Injury.11
301085872018CL-L1 and CL-K1 Exhibit Widespread Tissue Distribution With High and Co-Localized Expression in Secretory Epithelia and Mucosa.14

Citation

Dessen P

COLEC11 (collectin subfamily member 11)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62006/haematological-explorer/css/lib/haematological-explorer/