COPG1 (COPI coat complex subunit gamma 1)

2014-11-01  

Identity

HGNC
COPG1
LOCATION
3q21.3
LOCUSID
22820
ALIAS
COPG
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22820
MIM: 615525
HGNC: 2236
Ensembl: ENSG00000181789

Variants:

dbSNP: 22820
ClinVar: 22820
TCGA: ENSG00000181789
COSMIC: COPG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181789ENST00000314797Q9Y678
ENSG00000181789ENST00000504350D6RG17
ENSG00000181789ENST00000509889H0Y8X7
ENSG00000181789ENST00000514478H0Y8G2

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
335291662021Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex.9
335291662021Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex.9
325718742020The bacterial copper resistance protein CopG contains a cysteine-bridged tetranuclear copper cluster.9
325718742020The bacterial copper resistance protein CopG contains a cysteine-bridged tetranuclear copper cluster.9
286461282017γ-COPI mediates the retention of kAE1 G701D protein in Golgi apparatus - a mechanistic explanation of distal renal tubular acidosis associated with the G701D mutation.2
286461282017γ-COPI mediates the retention of kAE1 G701D protein in Golgi apparatus - a mechanistic explanation of distal renal tubular acidosis associated with the G701D mutation.2
234272612013Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP.29
234272612013Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP.29
204680642010Association study of 182 candidate genes in anorexia nervosa.32
204680642010Association study of 182 candidate genes in anorexia nervosa.32
146904972004Gamma-COP appendage domain - structure and function.37
146904972004Gamma-COP appendage domain - structure and function.37
118930852002Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus.8
118930852002Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus.8

Citation

Dessen P

COPG1 (COPI coat complex subunit gamma 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62022/img/js/deep-insight-explorer/