CORIN (corin, serine peptidase)

2014-11-01  

Identity

HGNC
CORIN
LOCATION
4p12
LOCUSID
10699
ALIAS
ATC2,CRN,Lrp4,PEE5,TMPRSS10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10699
MIM: 605236
HGNC: 19012
Ensembl: ENSG00000145244

Variants:

dbSNP: 10699
ClinVar: 10699
TCGA: ENSG00000145244
COSMIC: CORIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145244ENST00000273857Q9Y5Q5
ENSG00000145244ENST00000502252J3KR88
ENSG00000145244ENST00000504584J3KR83
ENSG00000145244ENST00000505909J3KR90
ENSG00000145244ENST00000508498E7EQE7
ENSG00000145244ENST00000610355A0A087X1D5

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Physiological factorsREACTOMER-HSA-5578768

References

Pubmed IDYearTitleCitations
384173052024Association between CORIN promoter methylation and hypertensive disorders of pregnancy - A nested case-control study.0
386572592024Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis.0
389427272024The endocrine basis of the cardio-renal axis: New perspectives regarding corin.1
384173052024Association between CORIN promoter methylation and hypertensive disorders of pregnancy - A nested case-control study.0
386572592024Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis.0
389427272024The endocrine basis of the cardio-renal axis: New perspectives regarding corin.1
379135062023Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis.2
379135062023Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis.2
351999422022Correlation between N-terminal pro-atrial natriuretic peptide, corin, and target organ damage in hypertensive disorders of pregnancy.3
358618352022Chronic Kidney Disease Is Associated With Increased Cardiac Corin Expression But Decreased Proatrial Natriuretic Peptide Conversion Activity.1
351999422022Correlation between N-terminal pro-atrial natriuretic peptide, corin, and target organ damage in hypertensive disorders of pregnancy.3
358618352022Chronic Kidney Disease Is Associated With Increased Cardiac Corin Expression But Decreased Proatrial Natriuretic Peptide Conversion Activity.1
343698812021Low serum corin levels predict end-organ damage in patients with hypertensive crisis.1
345928352021Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.9
348467822021Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults.9

Citation

Dessen P

CORIN (corin, serine peptidase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62031