DLST (dihydrolipoamide S-succinyltransferase)

2014-11-01  

Identity

HGNC
DLST
LOCATION
14q24.3
LOCUSID
1743
ALIAS
DLTS,KGD2,PGL7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1743
MIM: 126063
HGNC: 2911
Ensembl: ENSG00000119689

Variants:

dbSNP: 1743
ClinVar: 1743
TCGA: ENSG00000119689
COSMIC: DLST

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119689ENST00000238671B7ZAZ8
ENSG00000119689ENST00000334220P36957
ENSG00000119689ENST00000334220A0A024R6C9
ENSG00000119689ENST00000554612G3V498
ENSG00000119689ENST00000554806Q86SW4
ENSG00000119689ENST00000555089G3V5M3
ENSG00000119689ENST00000555492G3V5L9
ENSG00000119689ENST00000555988H0YJF9
ENSG00000119689ENST00000556460G3V3F0
ENSG00000119689ENST00000626051G3V5M3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Citrate cycle (TCA cycle)KEGGko00020
Lysine degradationKEGGko00310
Citrate cycle (TCA cycle)KEGGhsa00020
Lysine degradationKEGGhsa00310
Metabolic pathwaysKEGGhsa01100
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGhsa_M00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGhsa_M00032
Citrate cycle (TCA cycle, Krebs cycle)KEGGM00009
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGM00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGM00032
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Citrate cycle (TCA cycle, Krebs cycle)KEGGhsa_M00009
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Citric acid cycle (TCA cycle)REACTOMER-HSA-71403
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Lysine catabolismREACTOMER-HSA-71064
Glyoxylate metabolism and glycine degradationREACTOMER-HSA-389661
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
331809162021Germline DLST Variants Promote Epigenetic Modifications in Pheochromocytoma-Paraganglioma.7
342339242021Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma.26
331809162021Germline DLST Variants Promote Epigenetic Modifications in Pheochromocytoma-Paraganglioma.7
342339242021Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma.26
309297362019Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas.25
309297362019Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas.25
268765952016The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.28
268765952016The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.28
234758502013The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.22
234758502013The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.22
222356562011[2-Oxoglutarate dehydrogenase complex and its multipoint control].1
222356562011[2-Oxoglutarate dehydrogenase complex and its multipoint control].1
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

DLST (dihydrolipoamide S-succinyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62528/dlst-(dihydrolipoamide-s-succinyltransferase)