DOK6 (docking protein 6)

2014-11-01  

Identity

HGNC
DOK6
LOCATION
18q22.2
LOCUSID
220164
ALIAS
DOK5L,HsT3226
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 220164
MIM: 611402
HGNC: 28301
Ensembl: ENSG00000206052

Variants:

dbSNP: 220164
ClinVar: 220164
TCGA: ENSG00000206052
COSMIC: DOK6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000206052ENST00000382713Q6PKX4
ENSG00000206052ENST00000582992J3KTH4

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
RET signalingREACTOMER-HSA-8853659

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
345456882021Association between ABHD1 and DOK6 polymorphisms and susceptibility to Hirschsprung disease in Southern Chinese children.3
345456882021Association between ABHD1 and DOK6 polymorphisms and susceptibility to Hirschsprung disease in Southern Chinese children.3
202107982010Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.9
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
202107982010Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.9
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
152860812004Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.34
152860812004Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.34

Citation

Dessen P

DOK6 (docking protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62595