DTX2 (deltex E3 ubiquitin ligase 2)

2014-11-01  

Identity

HGNC
DTX2
LOCATION
7q11.23
LOCUSID
113878
ALIAS
RNF58
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 113878
MIM: 613141
HGNC: 15973
Ensembl: ENSG00000091073

Variants:

dbSNP: 113878
ClinVar: 113878
TCGA: ENSG00000091073
COSMIC: DTX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091073ENST00000324432Q86UW9
ENSG00000091073ENST00000413936Q86UW9
ENSG00000091073ENST00000423646C9JII1
ENSG00000091073ENST00000425780C9JVC8
ENSG00000091073ENST00000429179C9JEH4
ENSG00000091073ENST00000430490Q86UW9
ENSG00000091073ENST00000435251H7C3B8
ENSG00000091073ENST00000435861C9JY61
ENSG00000091073ENST00000438930C9JY61
ENSG00000091073ENST00000442516C9IYX1
ENSG00000091073ENST00000446600E7ET89
ENSG00000091073ENST00000446820Q86UW9
ENSG00000091073ENST00000451769C9JS11
ENSG00000091073ENST00000456590C9JLU8
ENSG00000091073ENST00000457529C9JF39

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370875772023[DTX2 overexpression promotes migration and invasion of colorectal cancer cells through the Notch2/Akt axis].2
370875772023[DTX2 overexpression promotes migration and invasion of colorectal cancer cells through the Notch2/Akt axis].2
172860442006cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos.2
172860442006cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos.2
126709572003The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.76
126709572003The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.76

Citation

Dessen P

DTX2 (deltex E3 ubiquitin ligase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62667/tumors-explorer/img/js/web-card-gene.js