DTX3 (deltex E3 ubiquitin ligase 3)

2014-11-01  

Identity

HGNC
DTX3
LOCATION
12q13.3
LOCUSID
196403
ALIAS
RNF154,deltex3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 196403
MIM: 613142
HGNC: 24457
Ensembl: ENSG00000178498

Variants:

dbSNP: 196403
ClinVar: 196403
TCGA: ENSG00000178498
COSMIC: DTX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178498ENST00000337737Q8N9I9
ENSG00000178498ENST00000337737A0A024RB96
ENSG00000178498ENST00000548198Q8N9I9
ENSG00000178498ENST00000548198A0A024RB96
ENSG00000178498ENST00000548478A0A0C4DGI8
ENSG00000178498ENST00000548804Q8N9I9
ENSG00000178498ENST00000548804A0A024RB96
ENSG00000178498ENST00000549583F8VUZ4
ENSG00000178498ENST00000550300H0YHF9
ENSG00000178498ENST00000550596A0A1Y8EH36
ENSG00000178498ENST00000551632Q8N9I9
ENSG00000178498ENST00000551835F8VV96

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366143042023Silencing DTX3L Inhibits the Progression of Cervical Carcinoma by Regulating PI3K/AKT/mTOR Signaling Pathway.2
366143042023Silencing DTX3L Inhibits the Progression of Cervical Carcinoma by Regulating PI3K/AKT/mTOR Signaling Pathway.2
336167742021DTX3 copy number increase in breast cancer: a study of associations to molecular subtype, proliferation and prognosis.6
336167742021DTX3 copy number increase in breast cancer: a study of associations to molecular subtype, proliferation and prognosis.6
318540422020Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma.17
318540422020Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma.17
170285732006Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains.100
170285732006Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains.100
126709572003The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.76
126709572003The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.76

Citation

Dessen P

DTX3 (deltex E3 ubiquitin ligase 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62668