DXO (decapping exoribonuclease)

2014-11-01  

Identity

HGNC
DXO
LOCATION
6p21.33
LOCUSID
1797
ALIAS
DOM3L,DOM3Z,NG6,RAI1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1797
MIM: 605996
HGNC: 2992
Ensembl: ENSG00000204348

Variants:

dbSNP: 1797
ClinVar: 1797
TCGA: ENSG00000204348
COSMIC: DXO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204348ENST00000337523O77932
ENSG00000204348ENST00000337523A0A024RCW8
ENSG00000204348ENST00000375349O77932
ENSG00000204348ENST00000375349A0A024RCW8
ENSG00000204348ENST00000375356O77932
ENSG00000204348ENST00000375356A0A024RCW8
ENSG00000204348ENST00000480240F8WC68
ENSG00000204348ENST00000495340H7C5D2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
2960158420182'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO.25
296727162018miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular pyrophosphatases, DOM3Z and DUSP11.39
2960158420182'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO.25
296727162018miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular pyrophosphatases, DOM3Z and DUSP11.39
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105

Citation

Dessen P

DXO (decapping exoribonuclease)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62684/gene-explorer/js/lib/deep-insight-explorer/