EHD4 (EH domain containing 4)

2014-11-01 Affiliation

Identity

HGNC

EHD4

LOCATION

15q15.1

LOCUSID

30844

ALIAS

PAST4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 30844
MIM: 605892
HGNC: 3245
Ensembl: ENSG00000103966

Variants:

dbSNP: 30844
ClinVar: 30844
TCGA: ENSG00000103966
COSMIC: EHD4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000103966	ENST00000220325	Q9H223
ENSG00000103966	ENST00000220325	A0A024R9N6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33972531	2021	A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.	16
33972531	2021	A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.	16
32800345	2020	Identification of phostensin in association with Eps 15 homology domain-containing protein 1 (EHD1) and EHD4.	0
32966336	2020	Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission.	6
32800345	2020	Identification of phostensin in association with Eps 15 homology domain-containing protein 1 (EHD1) and EHD4.	0
32966336	2020	Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission.	6
23325686	2013	Comparative proteomic analysis of HIV-1 particles reveals a role for Ezrin and EHD4 in the Nef-dependent increase of virus infectivity.	26
24019528	2013	Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.	37
23325686	2013	Comparative proteomic analysis of HIV-1 particles reveals a role for Ezrin and EHD4 in the Nef-dependent increase of virus infectivity.	26
24019528	2013	Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.	37
21187387	2011	Trk retrograde signaling requires persistent, Pincher-directed endosomes.	30
21187387	2011	Trk retrograde signaling requires persistent, Pincher-directed endosomes.	30
20489164	2010	EH domain proteins regulate cardiac membrane protein targeting.	46
20489164	2010	EH domain proteins regulate cardiac membrane protein targeting.	46
18331452	2008	A role for EHD4 in the regulation of early endosomal transport.	78

Citation

Dessen P

EHD4 (EH domain containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62763/js/css/lib/teaching-explorer/