EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha)

2014-11-01  

Identity

HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
EIF2B,EIF2BA

Other Information

Locus ID:

NCBI: 1967
MIM: 606686
HGNC: 3257
Ensembl: ENSG00000111361

Variants:

dbSNP: 1967
ClinVar: 1967
TCGA: ENSG00000111361
COSMIC: EIF2B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111361ENST00000424014Q14232
ENSG00000111361ENST00000534960H0YGG4
ENSG00000111361ENST00000537073Q14232
ENSG00000111361ENST00000539951F5H0D0

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Recycling of eIF2:GDPREACTOMER-HSA-72731
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
362428702022Shielding the mRNA-translation factor eIF2B from inhibitory p-eIF2 as a viral strategy to evade protein kinase R-mediated innate immunity.2
362428702022Shielding the mRNA-translation factor eIF2B from inhibitory p-eIF2 as a viral strategy to evade protein kinase R-mediated innate immunity.2
318825612020De Novo Mutations in EIF2B1 Affecting eIF2 Signaling Cause Neonatal/Early-Onset Diabetes and Transient Hepatic Dysfunction.15
318825612020De Novo Mutations in EIF2B1 Affecting eIF2 Signaling Cause Neonatal/Early-Onset Diabetes and Transient Hepatic Dysfunction.15
290364342017Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation.33
290364342017Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation.33
261127192015Different Eukaryotic Initiation Factor 2Bε Mutations Lead to Various Degrees of Intolerance to the Stress of Endoplasmic Reticulum in Oligodendrocytes.6
261127192015Different Eukaryotic Initiation Factor 2Bε Mutations Lead to Various Degrees of Intolerance to the Stress of Endoplasmic Reticulum in Oligodendrocytes.6
217953292011The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus.17
217953292011The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus.17
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
196316572009Crystal structure of the alpha subunit of human translation initiation factor 2B.18
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
196316572009Crystal structure of the alpha subunit of human translation initiation factor 2B.18

Citation

Dessen P

EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62773/case-report-explorer/css/lib/gene-explorer/