EIF2D (eukaryotic translation initiation factor 2D)

2014-11-01  

Identity

HGNC
EIF2D
LOCATION
1q32.1
LOCUSID
1939
ALIAS
HCA56,LGTN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1939
MIM: 613709
HGNC: 6583
Ensembl: ENSG00000143486

Variants:

dbSNP: 1939
ClinVar: 1939
TCGA: ENSG00000143486
COSMIC: EIF2D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143486ENST00000271764P41214
ENSG00000143486ENST00000367114P41214
ENSG00000143486ENST00000437518Q5SY38
ENSG00000143486ENST00000472709A0A087X1L6
ENSG00000143486ENST00000484492A0A087WVB6
ENSG00000143486ENST00000613435A0A087X202

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384331012024To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes.0
384331012024To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes.0
366895482023The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D.6
366895482023The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D.6
304192622019A novel uORF-based regulatory mechanism controls translation of the human MDM2 and eIF2D mRNAs during stress.7
309586012019Possible role of differentially expressing novel protein markers (ligatin and fibulin-7) in human aqueous humor and trabecular meshwork tissue in glaucoma progression.2
310786892019Time dependent expression of the blood biomarkers EIF2D and TOX in patients with schizophrenia.3
304192622019A novel uORF-based regulatory mechanism controls translation of the human MDM2 and eIF2D mRNAs during stress.7
309586012019Possible role of differentially expressing novel protein markers (ligatin and fibulin-7) in human aqueous humor and trabecular meshwork tissue in glaucoma progression.2
310786892019Time dependent expression of the blood biomarkers EIF2D and TOX in patients with schizophrenia.3
282403152017Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D.22
287325962017Structural and Functional Insights into Human Re-initiation Complexes.46
282403152017Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D.22
287325962017Structural and Functional Insights into Human Re-initiation Complexes.46

Citation

Dessen P

EIF2D (eukaryotic translation initiation factor 2D)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62777/gene-fusions-explorer/case-report-explorer/js/web-card-_common.js