EIF2D (eukaryotic translation initiation factor 2D)

2014-11-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
HCA56,LGTN
FUSION GENES

Other Information

Locus ID:

NCBI: 1939
MIM: 613709
HGNC: 6583
Ensembl: ENSG00000143486

Variants:

dbSNP: 1939
ClinVar: 1939
TCGA: ENSG00000143486
COSMIC: EIF2D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143486ENST00000271764P41214
ENSG00000143486ENST00000367114P41214
ENSG00000143486ENST00000437518Q5SY38
ENSG00000143486ENST00000472709A0A087X1L6
ENSG00000143486ENST00000484492A0A087WVB6
ENSG00000143486ENST00000613435A0A087X202

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384331012024To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes.0
384331012024To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes.0
366895482023The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D.6
366895482023The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D.6
304192622019A novel uORF-based regulatory mechanism controls translation of the human MDM2 and eIF2D mRNAs during stress.7
309586012019Possible role of differentially expressing novel protein markers (ligatin and fibulin-7) in human aqueous humor and trabecular meshwork tissue in glaucoma progression.2
310786892019Time dependent expression of the blood biomarkers EIF2D and TOX in patients with schizophrenia.3
304192622019A novel uORF-based regulatory mechanism controls translation of the human MDM2 and eIF2D mRNAs during stress.7
309586012019Possible role of differentially expressing novel protein markers (ligatin and fibulin-7) in human aqueous humor and trabecular meshwork tissue in glaucoma progression.2
310786892019Time dependent expression of the blood biomarkers EIF2D and TOX in patients with schizophrenia.3
282403152017Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D.22
287325962017Structural and Functional Insights into Human Re-initiation Complexes.46
282403152017Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D.22
287325962017Structural and Functional Insights into Human Re-initiation Complexes.46

Citation

Dessen P

EIF2D (eukaryotic translation initiation factor 2D)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62777/gene-fusions/css/lib/cancer-prone-explorer/