EMC4 (ER membrane protein complex subunit 4)

2014-11-01  

Identity

HGNC
EMC4
LOCATION
15q14
LOCUSID
51234
ALIAS
PIG17,TMEM85

Other Information

Locus ID:

NCBI: 51234
MIM: 616245
HGNC: 28032
Ensembl: ENSG00000128463

Variants:

dbSNP: 51234
ClinVar: 51234
TCGA: ENSG00000128463
COSMIC: EMC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128463ENST00000249209Q5J8M3
ENSG00000128463ENST00000249209A0A0S2Z598
ENSG00000128463ENST00000267750Q5J8M3
ENSG00000128463ENST00000267750A0A024R9N3
ENSG00000128463ENST00000557879S4R329
ENSG00000128463ENST00000558102H0YN63
ENSG00000128463ENST00000558205H0YNK0
ENSG00000128463ENST00000559078H0YNK8
ENSG00000128463ENST00000559421H0YK61
ENSG00000128463ENST00000560911H0YMH5
ENSG00000128463ENST00000560947H0YKL2
ENSG00000128463ENST00000561372H0YLP8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
321118412020Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry.14
321118412020Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry.14
185860322008Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast.8
185860322008Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast.8

Citation

Dessen P

EMC4 (ER membrane protein complex subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62813/case-report-explorer/cancer-prone-explorer/css/card-gene.css