FAM111A (FAM111 trypsin like peptidase A)

2014-11-01  

Identity

HGNC
FAM111A
LOCATION
11q12.1
LOCUSID
63901
ALIAS
GCLEB,KCS2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 63901
MIM: 615292
HGNC: 24725
Ensembl: ENSG00000166801

Variants:

dbSNP: 63901
ClinVar: 63901
TCGA: ENSG00000166801
COSMIC: FAM111A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166801ENST00000361723Q96PZ2
ENSG00000166801ENST00000361723A0A024R4Z3
ENSG00000166801ENST00000420244Q96PZ2
ENSG00000166801ENST00000420244A0A024R4Z3
ENSG00000166801ENST00000527629E9PR18
ENSG00000166801ENST00000528737Q96PZ2
ENSG00000166801ENST00000528737A0A024R4Z3
ENSG00000166801ENST00000531147Q96PZ2
ENSG00000166801ENST00000531147A0A024R4Z3
ENSG00000166801ENST00000531408E9PNQ0
ENSG00000166801ENST00000533703Q96PZ2
ENSG00000166801ENST00000533703A0A024R4Z3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384740922024Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications.0
384740922024Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications.0
374009942023N(6) -methyladenosine-modified FAM111A-DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A.6
376072342023Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1.3
377937782023FAM111A regulates replication origin activation and cell fitness.5
374009942023N(6) -methyladenosine-modified FAM111A-DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A.6
376072342023Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1.3
377937782023FAM111A regulates replication origin activation and cell fitness.5
332631872021Adult Chinese twins with Kenny-Caffey syndrome type 2: A potential age-dependent phenotype and review of literature.9
333698672021FAM111A induces nuclear dysfunction in disease and viral restriction.18
337500162021Report of a novel variant in the FAM111A gene in a fetus with multiple anomalies including gracile bones, hypoplastic spleen, and hypomineralized skull.8
349303592021IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3.3
332631872021Adult Chinese twins with Kenny-Caffey syndrome type 2: A potential age-dependent phenotype and review of literature.9
333698672021FAM111A induces nuclear dysfunction in disease and viral restriction.18
337500162021Report of a novel variant in the FAM111A gene in a fetus with multiple anomalies including gracile bones, hypoplastic spleen, and hypomineralized skull.8

Citation

Dessen P

FAM111A (FAM111 trypsin like peptidase A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62993