FBXL19 (F-box and leucine rich repeat protein 19)

2014-11-01 Affiliation

Identity

HGNC

FBXL19

LOCATION

16p11.2

LOCUSID

54620

ALIAS

CXXC11,Fbl19,JHDM1C

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54620
MIM: 609085
HGNC: 25300
Ensembl: ENSG00000099364

Variants:

dbSNP: 54620
ClinVar: 54620
TCGA: ENSG00000099364
COSMIC: FBXL19

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000099364	ENST00000338343	H3BPZ0
ENSG00000099364	ENST00000380310	Q6PCT2
ENSG00000099364	ENST00000427128	H7C112
ENSG00000099364	ENST00000471231	H3BVB1
ENSG00000099364	ENST00000562319	H3BPZ0
ENSG00000099364	ENST00000562798	H3BQP6
ENSG00000099364	ENST00000565690	H3BME1
ENSG00000099364	ENST00000565939	H3BTJ3
ENSG00000099364	ENST00000566320	H3BPI8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164713366	Tumor necrosis factor alpha (TNF-alpha) inhibitors	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	26194362
PA445451	Psoriasis	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	26194362

References

Pubmed ID	Year	Title	Citations
34278444	2021	FBXL19‑AS1 promotes the progression of nasopharyngeal carcinoma by acting as a competing endogenous RNA to sponge miR‑431 and upregulate PBOV1.	1
34278444	2021	FBXL19‑AS1 promotes the progression of nasopharyngeal carcinoma by acting as a competing endogenous RNA to sponge miR‑431 and upregulate PBOV1.	1
31566718	2020	Long noncoding RNA FBXL19-AS1 induces tumor growth and metastasis by sponging miR-203a-3p in lung adenocarcinoma.	14
31566718	2020	Long noncoding RNA FBXL19-AS1 induces tumor growth and metastasis by sponging miR-203a-3p in lung adenocarcinoma.	14
24684802	2014	F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation.	34
24684802	2014	F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation.	34
20953189	2010	Genome-wide association analysis identifies three psoriasis susceptibility loci.	143
20953189	2010	Genome-wide association analysis identifies three psoriasis susceptibility loci.	143

Citation

Dessen P

FBXL19 (F-box and leucine rich repeat protein 19)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63315