FBXO21 (F-box protein 21)

2014-11-01  

Identity

HGNC
FBXO21
LOCATION
12q24.22
LOCUSID
23014
ALIAS
FBX21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23014
MIM: 609095
HGNC: 13592
Ensembl: ENSG00000135108

Variants:

dbSNP: 23014
ClinVar: 23014
TCGA: ENSG00000135108
COSMIC: FBXO21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135108ENST00000330622O94952
ENSG00000135108ENST00000330622A0A024RBR2
ENSG00000135108ENST00000427718Q4G104
ENSG00000135108ENST00000548840H0YHF6
ENSG00000135108ENST00000550180H0YIE9
ENSG00000135108ENST00000622495O94952
ENSG00000135108ENST00000622495A0A024RBL8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseVariantAnnotationnot associatedPD29938344
PA449165cyclophosphamideChemicalVariantAnnotationnot associatedPD29938344
PA449412doxorubicinChemicalVariantAnnotationnot associatedPD29938344

References

Pubmed IDYearTitleCitations
376898252023FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.0
376898252023FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.0
362788142022circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis.3
362788142022circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis.3
334501322021JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy.26
334501322021JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy.26
260853302015FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.6
262996182015CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination.27
266317462015Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.10
260853302015FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.6
262996182015CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination.27
266317462015Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.10

Citation

Dessen P

FBXO21 (F-box protein 21)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63325/tumors-explorer/case-report-explorer/