FBXO21 (F-box protein 21)

2014-11-01  

Identity

HGNC
LOCATION
12q24.22
LOCUSID
ALIAS
FBX21
FUSION GENES

Other Information

Locus ID:

NCBI: 23014
MIM: 609095
HGNC: 13592
Ensembl: ENSG00000135108

Variants:

dbSNP: 23014
ClinVar: 23014
TCGA: ENSG00000135108
COSMIC: FBXO21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135108ENST00000330622O94952
ENSG00000135108ENST00000330622A0A024RBR2
ENSG00000135108ENST00000427718Q4G104
ENSG00000135108ENST00000548840H0YHF6
ENSG00000135108ENST00000550180H0YIE9
ENSG00000135108ENST00000622495O94952
ENSG00000135108ENST00000622495A0A024RBL8

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseVariantAnnotationnot associatedPD29938344
PA449165cyclophosphamideChemicalVariantAnnotationnot associatedPD29938344
PA449412doxorubicinChemicalVariantAnnotationnot associatedPD29938344

References

Pubmed IDYearTitleCitations
376898252023FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.0
376898252023FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.0
362788142022circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis.3
362788142022circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis.3
334501322021JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy.26
334501322021JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy.26
260853302015FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.6
262996182015CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination.27
266317462015Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.10
260853302015FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.6
262996182015CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination.27
266317462015Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.10

Citation

Dessen P

FBXO21 (F-box protein 21)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63325/tumors-explorer/haematological-explorer/