FPR3 (formyl peptide receptor 3)

2014-11-01  

Identity

HGNC
FPR3
LOCATION
19q13.41
LOCUSID
2359
ALIAS
FML2_HUMAN,FMLP-R-II,FMLPY,FPRH1,FPRH2,FPRL2,RMLP-R-I

Other Information

Locus ID:

NCBI: 2359
MIM: 136539
HGNC: 3828
Ensembl: ENSG00000187474

Variants:

dbSNP: 2359
ClinVar: 2359
TCGA: ENSG00000187474
COSMIC: FPR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187474ENST00000339223P25089
ENSG00000187474ENST00000339223Q6L5J4
ENSG00000187474ENST00000595991P25089
ENSG00000187474ENST00000595991Q6L5J4

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Formyl peptide receptors bind formyl peptides and many other ligandsREACTOMER-HSA-444473
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
386143852024FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.0
386143852024FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.0
367506932023Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.6
367506932023Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.6
321527572020D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.5
321527572020D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.5
311167812019Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients.5
311167812019Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients.5
294276632018Intracellular formyl peptide receptor regulates naïve CD4 T cell migration.7
295445242018Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease.15
294276632018Intracellular formyl peptide receptor regulates naïve CD4 T cell migration.7
295445242018Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease.15
237461122013Evaluation of cell-free expression system for the production of soluble and functional human GPCR N-formyl peptide receptors.2
240674612013Helicobacter pylori HP(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates VEGF-alpha and TGF-beta release by interacting with formyl-peptide receptors.10
237461122013Evaluation of cell-free expression system for the production of soluble and functional human GPCR N-formyl peptide receptors.2

Citation

Dessen P

FPR3 (formyl peptide receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63581