G6PC2 (glucose-6-phosphatase catalytic subunit 2)

2014-11-01  

Identity

HGNC
G6PC2
LOCATION
2q31.1
LOCUSID
57818
ALIAS
IGRP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57818
MIM: 608058
HGNC: 28906
Ensembl: ENSG00000152254

Variants:

dbSNP: 57818
ClinVar: 57818
TCGA: ENSG00000152254
COSMIC: G6PC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152254ENST00000282075Q9NQR9
ENSG00000152254ENST00000375363Q9NQR9
ENSG00000152254ENST00000421979C9IYU7
ENSG00000152254ENST00000429379Q9NQR9

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Galactose metabolismKEGGko00052
Starch and sucrose metabolismKEGGko00500
Insulin signaling pathwayKEGGko04910
Adipocytokine signaling pathwayKEGGko04920
Glycolysis / GluconeogenesisKEGGhsa00010
Galactose metabolismKEGGhsa00052
Starch and sucrose metabolismKEGGhsa00500
Insulin signaling pathwayKEGGhsa04910
Adipocytokine signaling pathwayKEGGhsa04920
Metabolic pathwaysKEGGhsa01100
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
FoxO signaling pathwayKEGGhsa04068
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Hexose transportREACTOMER-HSA-189200
Glucose transportREACTOMER-HSA-70153
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Insulin resistanceKEGGhsa04931

References

Pubmed IDYearTitleCitations
380950632024Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model.0
380950632024Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model.0
378553662023G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity.1
378553662023G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity.1
352771942022G6PC indicated poor prognosis in cervical cancer and promoted cervical carcinogenesis in vitro and in vivo.9
355341122022Mutations in G6PC2 gene with increased risk for development of type 2 diabetes: Understanding via computational approach.4
356579902022Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.2
352771942022G6PC indicated poor prognosis in cervical cancer and promoted cervical carcinogenesis in vitro and in vivo.9
355341122022Mutations in G6PC2 gene with increased risk for development of type 2 diabetes: Understanding via computational approach.4
356579902022Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.2
338429832021Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose.7
341282142021Haplotypes of the genes (GCK and G6PC2) underlying the glucose/glucose-6-phosphate cycle are associated with pancreatic beta cell glucose sensitivity in patients with newly diagnosed type 2 diabetes from the VNDS study (VNDS 11).0
338429832021Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose.7
341282142021Haplotypes of the genes (GCK and G6PC2) underlying the glucose/glucose-6-phosphate cycle are associated with pancreatic beta cell glucose sensitivity in patients with newly diagnosed type 2 diabetes from the VNDS study (VNDS 11).0
322136542020Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose.13

Citation

Dessen P

G6PC2 (glucose-6-phosphatase catalytic subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63639