ANGPT2 (angiopoietin 2)

2003-05-01  

Identity

HGNC
ANGPT2
LOCATION
8p23.1
LOCUSID
285
ALIAS
AGPT2,ANG2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 285
MIM: 601922
HGNC: 485
Ensembl: ENSG00000091879

Variants:

dbSNP: 285
ClinVar: 285
TCGA: ENSG00000091879
COSMIC: ANGPT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091879ENST00000325203O15123
ENSG00000091879ENST00000338312O15123
ENSG00000091879ENST00000523120E7EVQ3
ENSG00000091879ENST00000629816O15123

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Tie2 SignalingREACTOMER-HSA-210993

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384852502024Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study.0
387751532024Blocking the angiopoietin-2-dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis.0
384852502024Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study.0
387751532024Blocking the angiopoietin-2-dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis.0
356573102023Reduced Angiopoietin Factor 2 Levels Are Correlated with Better Cardiac Function and Prognosis in Valvular Heart Disease.1
366090912023Angiopoietin 2 and hsCRP are associated with pulmonary hemodynamics and long-term mortality respectively in CTEPH-Results from a prospective discovery and validation biomarker study.2
366628912023Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy.5
366802212023Serum Angiopoietin-2 Predicts the Occurrence and Recurrence of Hepatocellular Carcinoma after Direct-Acting Antiviral Therapy for Hepatitis C.0
368774452023Helicobacter pylori infection induces abnormal expression of pro-angiogenic gene ANGPT2 and miR-203a in AGS gastric cell line.0
369078782023Homeobox D9 drives the malignant phenotypes and enhances the Programmed death ligand-1 expression in non-small cell lung cancer cells via binding to Angiopoietin-2 promoter.1
370009172023von Willebrand Factor and Angiopoietin-2 are Sensitive Biomarkers of Pulsatility in Continuous-Flow Ventricular Assist Device Patients.0
370117102023von Willebrand factor binds to angiopoietin-2 within endothelial cells and after release from Weibel-Palade bodies.5
372901242023Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization.1
373121692023Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.3
373660842023Diagnostic and prognostic value of Ang-2 in ARDS: a systemic review and meta-analysis.1

Citation

Dessen P

ANGPT2 (angiopoietin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/637/deep-insight-explorer/img/gene-explorer/