GET4 (guided entry of tail-anchored proteins factor 4)

2014-11-01  

Identity

HGNC
GET4
LOCATION
7p22.3
LOCUSID
51608
ALIAS
C7orf20,CEE,CGI-20,TRC35
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51608
MIM: 612056
HGNC: 21690
Ensembl: ENSG00000239857

Variants:

dbSNP: 51608
ClinVar: 51608
TCGA: ENSG00000239857
COSMIC: GET4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000239857ENST00000265857Q7L5D6
ENSG00000239857ENST00000407192Q7L5D6
ENSG00000239857ENST00000412734C9JPA8
ENSG00000239857ENST00000426056C9JY46
ENSG00000239857ENST00000441491C9JHN8

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
347043382022GET4 is a novel driver gene in colorectal cancer that regulates the localization of BAG6, a nucleocytoplasmic shuttling protein.5
347043382022GET4 is a novel driver gene in colorectal cancer that regulates the localization of BAG6, a nucleocytoplasmic shuttling protein.5
255353732015Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.50
255353732015Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.50
247278352014Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.33
247278352014Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.33
236655632013A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.47
237230672013Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.23
236655632013A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.47
237230672013Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.23
232460012012SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.59
232460012012SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.59

Citation

Dessen P

GET4 (guided entry of tail-anchored proteins factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63753/gene-explorer/js/lib/jquery-3.5.1.min.js