ANGPT4 (angiopoietin 4)

2003-05-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
ANG3,ANG4

Other Information

Locus ID:

NCBI: 51378
MIM: 603705
HGNC: 487
Ensembl: ENSG00000101280

Variants:

dbSNP: 51378
ClinVar: 51378
TCGA: ENSG00000101280
COSMIC: ANGPT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101280ENST00000381922Q9Y264

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Tie2 SignalingREACTOMER-HSA-210993

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
309574372020Dual functional nanoparticles containing SOX duo and ANGPT4 shRNA for osteoarthritis treatment.6
309574372020Dual functional nanoparticles containing SOX duo and ANGPT4 shRNA for osteoarthritis treatment.6
259772562015Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation.9
259772562015Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation.9
247601482014Acute-phase protein α1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion.13
247601482014Acute-phase protein α1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion.13
222677462012Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.55
222677462012Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.55
216036282011Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2.19
216036282011Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2.19
205960412010Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer's disease and vascular dementia.7
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.26
208231542010Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis.30
205960412010Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer's disease and vascular dementia.7

Citation

Dessen P

ANGPT4 (angiopoietin 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/638/angpt4