GPR119 (G protein-coupled receptor 119)

2014-11-01  

Identity

HGNC
GPR119
LOCATION
Xq26.1
LOCUSID
139760
ALIAS
GPCR2

Other Information

Locus ID:

NCBI: 139760
MIM: 300513
HGNC: 19060
Ensembl: ENSG00000147262

Variants:

dbSNP: 139760
ClinVar: 139760
TCGA: ENSG00000147262
COSMIC: GPR119

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147262ENST00000276218Q8TDV5

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Insulin secretionKEGGhsa04911
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)REACTOMER-HSA-400511

References

Pubmed IDYearTitleCitations
332423252021Screening for bacterial enzymes synthesizing GPR119 agonist in cAMP-responsive cells.0
350492252021GPR116 overexpression correlates with poor prognosis in gastric cancer.3
332423252021Screening for bacterial enzymes synthesizing GPR119 agonist in cAMP-responsive cells.0
350492252021GPR116 overexpression correlates with poor prognosis in gastric cancer.3
321427972020GPR119 Is a Potent Regulator of Human Sebocyte Biology.6
321427972020GPR119 Is a Potent Regulator of Human Sebocyte Biology.6
298837992018Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119.6
298837992018Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119.6
273918142016Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119.8
273918142016Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119.8
238971632014Novel GPR119 agonist HD0471042 attenuated type 2 diabetes mellitus.6
244938332014A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.60
246818962014Discovery and characterization of novel small molecule agonists of G protein-coupled receptor 119.4
238971632014Novel GPR119 agonist HD0471042 attenuated type 2 diabetes mellitus.6
244938332014A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.60

Citation

Dessen P

GPR119 (G protein-coupled receptor 119)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63949