GRM7 (glutamate metabotropic receptor 7)

2014-11-01 Affiliation

Identity

HGNC

GRM7

LOCATION

3p26.1

LOCUSID

2917

ALIAS

GLUR7,GPRC1G,MGLU7,MGLUR7,NEDSHBA,PPP1R87

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2917
MIM: 604101
HGNC: 4599
Ensembl: ENSG00000196277

Variants:

dbSNP: 2917
ClinVar: 2917
TCGA: ENSG00000196277
COSMIC: GRM7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196277	ENST00000357716	Q14831
ENSG00000196277	ENST00000389335	Q14831
ENSG00000196277	ENST00000389336	Q14831
ENSG00000196277	ENST00000402647	A0A0A0MSC3
ENSG00000196277	ENST00000435689	F8WAW6
ENSG00000196277	ENST00000440923	H7C3K2
ENSG00000196277	ENST00000443259	F8WCR9
ENSG00000196277	ENST00000445087	C9JMT3
ENSG00000196277	ENST00000448328	C9JU97
ENSG00000196277	ENST00000467425	Q14831
ENSG00000196277	ENST00000486284	Q14831

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)	REACTOME	R-HSA-420499
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA447197	Attention Deficit Disorder with Hyperactivity	Disease	VariantAnnotation	not associated	PD
PA450464	methylphenidate	Chemical	VariantAnnotation	not associated	PD
PA451257	risperidone	Chemical	ClinicalAnnotation	associated	PD	26905411

References

Pubmed ID	Year	Title	Citations
38070825	2024	GRM7-related disorder: five additional patients from three independent families and review of the literature.	2
38070825	2024	GRM7-related disorder: five additional patients from three independent families and review of the literature.	2
36597080	2023	Correlation between variants of the CREB1 and GRM7 genes and risk of depression.	2
37003303	2023	GRM7 gene mutations and consequences for neurodevelopment.	2
37882887	2023	Associations between GRM7 polymorphisms and obesity in patients selected for sleeve gastrectomy.	0
36597080	2023	Correlation between variants of the CREB1 and GRM7 genes and risk of depression.	2
37003303	2023	GRM7 gene mutations and consequences for neurodevelopment.	2
37882887	2023	Associations between GRM7 polymorphisms and obesity in patients selected for sleeve gastrectomy.	0
32624350	2022	A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis.	6
32624350	2022	A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis.	6
33068816	2021	Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.	6
33476302	2021	A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.	13
34135509	2021	Structures of human mGlu2 and mGlu7 homo- and heterodimers.	47
34273994	2021	A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity.	3
33068816	2021	Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.	6

Citation

Dessen P

GRM7 (glutamate metabotropic receptor 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64053/favicon/tumors-explorer/favicon/manifest.json