GSAP (gamma-secretase activating protein)

2014-11-01  

Identity

HGNC
GSAP
LOCATION
7q11.23
LOCUSID
54103
ALIAS
PION
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54103
MIM: 613552
HGNC: 28042
Ensembl: ENSG00000186088

Variants:

dbSNP: 54103
ClinVar: 54103
TCGA: ENSG00000186088
COSMIC: GSAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186088ENST00000257626A4D1B5
ENSG00000186088ENST00000415112H7C0Q7
ENSG00000186088ENST00000430584C9JRG7
ENSG00000186088ENST00000441833B7ZL33

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
341564242021GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.12
341564242021GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.12
287431262017Frontal Cortex and Hippocampal γ-Secretase Activating Protein Levels in Prodromal Alzheimer Disease.6
287431262017Frontal Cortex and Hippocampal γ-Secretase Activating Protein Levels in Prodromal Alzheimer Disease.6
260769912015Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence.8
260769912015Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence.8
250372852014Common GSAP promoter variant contributes to Alzheimer's disease liability.13
250372852014Common GSAP promoter variant contributes to Alzheimer's disease liability.13
232092902013The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.20
232092902013The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.20
217183432012Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.14
226810442012Purification and characterization of the human γ-secretase activating protein.9
217183432012Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.14
226810442012Purification and characterization of the human γ-secretase activating protein.9
208114582010Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.115

Citation

Dessen P

GSAP (gamma-secretase activating protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64070