HMCES (5-hydroxymethylcytosine binding, ES cell specific)

2014-11-01  

Identity

HGNC
HMCES
LOCATION
3q21.3
LOCUSID
56941
ALIAS
C3orf37,DC12,SRAPD1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56941
MIM: 618288
HGNC: 24446
Ensembl: ENSG00000183624

Variants:

dbSNP: 56941
ClinVar: 56941
TCGA: ENSG00000183624
COSMIC: HMCES

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183624ENST00000383463Q96FZ2
ENSG00000183624ENST00000389735Q96FZ2
ENSG00000183624ENST00000417226E7EMP6
ENSG00000183624ENST00000502878Q96FZ2
ENSG00000183624ENST00000509042D6R9T3
ENSG00000183624ENST00000509551D6RAZ3
ENSG00000183624ENST00000510314D6RGK7
ENSG00000183624ENST00000511665D6RAI0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
337888312021Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells.15
337888312021Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells.15
319923572020Characterization of global 5-hydroxymethylcytosine in pediatric posterior fossa ependymoma.3
323078242020HMCES safeguards replication from oxidative stress and ensures error-free repair.17
324924212020HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation.32
326637912020Structural biology of DNA abasic site protection by SRAP proteins.10
3320343620205-Hydroxymethylation highlights the heterogeneity in keratinization and cell junctions in head and neck cancers.8
319923572020Characterization of global 5-hydroxymethylcytosine in pediatric posterior fossa ependymoma.3
323078242020HMCES safeguards replication from oxidative stress and ensures error-free repair.17
324924212020HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation.32
326637912020Structural biology of DNA abasic site protection by SRAP proteins.10
3320343620205-Hydroxymethylation highlights the heterogeneity in keratinization and cell junctions in head and neck cancers.8
312359132019Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.31
312359132019Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.31
2547135120155-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.12

Citation

Dessen P

HMCES (5-hydroxymethylcytosine binding, ES cell specific)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64342/meetings/gene-fusions-explorer/