HTR6 (5-hydroxytryptamine receptor 6)

2014-11-01  

Identity

HGNC
HTR6
LOCATION
1p36.13
LOCUSID
3362
ALIAS
5-HT6,5-HT6R

Other Information

Locus ID:

NCBI: 3362
MIM: 601109
HGNC: 5301
Ensembl: ENSG00000158748

Variants:

dbSNP: 3362
ClinVar: 3362
TCGA: ENSG00000158748
COSMIC: HTR6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158748ENST00000289753P50406

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Serotonergic synapseKEGGhsa04726
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Serotonin receptorsREACTOMER-HSA-390666
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA175GNASGenePathwayassociated19741567
PA444545HyperprolactinemiaDiseaseVariantAnnotationassociatedPD19997080
PA447198Autistic DisorderDiseaseVariantAnnotationassociatedPD19997080
PA451257risperidoneChemicalVariantAnnotationassociatedPD19997080

References

Pubmed IDYearTitleCitations
380864482024Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension.1
380864482024Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension.1
353599702022Systematic Analysis of Neurotransmitter Receptors in Human Breast Cancer Reveals a Strong Association With Outcome and Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating the Immune Microenvironment.0
353599702022Systematic Analysis of Neurotransmitter Receptors in Human Breast Cancer Reveals a Strong Association With Outcome and Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating the Immune Microenvironment.0
333574072021Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors.8
333720372021HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.13
340031042021[5-HT(6) receptor-mTOR: An hyperactive couple in neuropathic pain].0
333574072021Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors.8
333720372021HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.13
340031042021[5-HT(6) receptor-mTOR: An hyperactive couple in neuropathic pain].0
315873662020Correlation of 5-HTR6 gene polymorphism with vestibular migraine.4
324177742020Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer's Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P.1
315873662020Correlation of 5-HTR6 gene polymorphism with vestibular migraine.4
324177742020Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer's Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P.1
2503446320155-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy.8

Citation

Dessen P

HTR6 (5-hydroxytryptamine receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64474