IFIT5 (interferon induced protein with tetratricopeptide repeats 5)

2014-11-01  

Identity

HGNC
IFIT5
LOCATION
10q23.31
LOCUSID
24138
ALIAS
ISG58,P58,RI58
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 24138
MIM: 616135
HGNC: 13328
Ensembl: ENSG00000152778

Variants:

dbSNP: 24138
ClinVar: 24138
TCGA: ENSG00000152778
COSMIC: IFIT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152778ENST00000371795Q13325

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
338589622021IFIT5 Negatively Regulates the Type I IFN Pathway by Disrupting TBK1-IKKε-IRF3 Signalosome and Degrading IRF3 and IKKε.9
347632332021Comprehensive analysis of the prognosis and biological significance for IFIT family in skin cutaneous melanoma.7
338589622021IFIT5 Negatively Regulates the Type I IFN Pathway by Disrupting TBK1-IKKε-IRF3 Signalosome and Degrading IRF3 and IKKε.9
347632332021Comprehensive analysis of the prognosis and biological significance for IFIT family in skin cutaneous melanoma.7
329628612020Development of bis-ANS-based modified fluorescence titration assay for IFIT/RNA studies.1
329628612020Development of bis-ANS-based modified fluorescence titration assay for IFIT/RNA studies.1
311646322019The roles and mechanism of IFIT5 in bladder cancer epithelial-mesenchymal transition and progression.17
311646322019The roles and mechanism of IFIT5 in bladder cancer epithelial-mesenchymal transition and progression.17
263343752015IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1).22
263343752015IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1).22
250923122014Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5.56
250923122014Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5.56
233175052013tRNA binding, structure, and localization of the human interferon-induced protein IFIT5.54
233344202013Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.131
237742682013Crystal structure and nucleotide selectivity of human IFIT5/ISG58.23

Citation

Dessen P

IFIT5 (interferon induced protein with tetratricopeptide repeats 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64510/js/lib/deep-insight-explorer/