INSC (INSC spindle orientation adaptor protein)

2014-11-01  

Identity

HGNC
INSC
LOCATION
11p15.2
LOCUSID
387755
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 387755
MIM: 610668
HGNC: 33116
Ensembl: ENSG00000188487

Variants:

dbSNP: 387755
ClinVar: 387755
TCGA: ENSG00000188487
COSMIC: INSC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188487ENST00000379554Q1MX18
ENSG00000188487ENST00000379556Q1MX18
ENSG00000188487ENST00000424273A0A0A0MSI1
ENSG00000188487ENST00000525218Q1MX18
ENSG00000188487ENST00000528567Q1MX18
ENSG00000188487ENST00000530161Q1MX18

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
342247942021Genome-wide association study identified INSC gene associated with Trail Making Test Part A and Alzheimer's disease related cognitive phenotypes.6
342247942021Genome-wide association study identified INSC gene associated with Trail Making Test Part A and Alzheimer's disease related cognitive phenotypes.6
295237892018Insc:LGN tetramers promote asymmetric divisions of mammary stem cells.18
295237892018Insc:LGN tetramers promote asymmetric divisions of mammary stem cells.18
229777352012On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN.22
229777352012On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN.22
220748472011Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN).38
220748472011Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN).38
200650322010Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable.18
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
200650322010Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable.18
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
164588562006Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.12
164588562006Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.12

Citation

Dessen P

INSC (INSC spindle orientation adaptor protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64622/case-report-explorer/js/_common.js