LAMTOR4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4)

2014-11-01 Affiliation

Identity

HGNC

LAMTOR4

LOCATION

7q22.1

LOCUSID

389541

ALIAS

C7orf59

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 389541
MIM: 618834
HGNC: 33772
Ensembl: ENSG00000188186

Variants:

dbSNP: 389541
ClinVar: 389541
TCGA: ENSG00000188186
COSMIC: LAMTOR4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000188186	ENST00000341942	Q0VGL1
ENSG00000188186	ENST00000441173	C9JXA7
ENSG00000188186	ENST00000460732	A0A087WV46
ENSG00000188186	ENST00000466498	A0A087WWR0
ENSG00000188186	ENST00000468582	A0A087WVU0
ENSG00000188186	ENST00000473459	A0A087WVU0
ENSG00000188186	ENST00000474141	A0A087WT92
ENSG00000188186	ENST00000488241	A0A087WVK8
ENSG00000188186	ENST00000490633	A0A087WXQ3

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
mTOR signaling pathway	KEGG	ko04150
mTOR signaling pathway	KEGG	hsa04150
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
PKB-mediated events	REACTOME	R-HSA-109703
mTOR signalling	REACTOME	R-HSA-165159
mTORC1-mediated signalling	REACTOME	R-HSA-166208
Energy dependent regulation of mTOR by LKB1-AMPK	REACTOME	R-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Cellular responses to stress	REACTOME	R-HSA-2262752
Macroautophagy	REACTOME	R-HSA-1632852

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36336962	2023	Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis.	3
36336962	2023	Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis.	3
31314152	2019	C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly.	4
31314152	2019	C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly.	4
22980980	2012	Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.	493
22980980	2012	Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.	493

Citation

Dessen P

LAMTOR4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/65167