APCDD1 (APC down-regulated 1)

2003-02-01  

Identity

HGNC
APCDD1
LOCATION
18p11.22
LOCUSID
147495
ALIAS
B7323,DRAPC1,FP7019,HHS,HTS,HYPT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 147495
MIM: 607479
HGNC: 15718
Ensembl: ENSG00000154856

Variants:

dbSNP: 147495
ClinVar: 147495
TCGA: ENSG00000154856
COSMIC: APCDD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154856ENST00000355285Q8J025
ENSG00000154856ENST00000423585X6RH63
ENSG00000154856ENST00000578882J3KTQ6
ENSG00000154856ENST00000579685J3QSE3
ENSG00000154856ENST00000582723J3KTR1
ENSG00000154856ENST00000584596V9GY82

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
336732792021Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal Cancer.5
336732792021Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal Cancer.5
304964862019Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1.34
304964862019Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1.34
282427652017A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.15
286981412017Epigenetic silencing of the Wnt antagonist APCDD1 by promoter DNA hyper-methylation contributes to osteosarcoma cell invasion and metastasis.11
282427652017A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.15
286981412017Epigenetic silencing of the Wnt antagonist APCDD1 by promoter DNA hyper-methylation contributes to osteosarcoma cell invasion and metastasis.11
255929702015The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells.12
259466822015Apcdd1 stimulates oligodendrocyte differentiation after white matter injury.15
255929702015The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells.12
259466822015Apcdd1 stimulates oligodendrocyte differentiation after white matter injury.15
225128112012A recurrent mutation in the APCDD1 gene responsible for hereditary hypotrichosis simplex in a large Chinese family.1
225128112012A recurrent mutation in the APCDD1 gene responsible for hereditary hypotrichosis simplex in a large Chinese family.1
202009782010Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.8

Citation

Dessen P

APCDD1 (APC down-regulated 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/667/js/lib/js/lib/tumors-explorer/