ATG4B (autophagy related 4B cysteine peptidase)

2003-10-01  

Identity

HGNC
ATG4B
LOCATION
2q37.3
LOCUSID
23192
ALIAS
APG4B,AUTL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23192
MIM: 611338
HGNC: 20790
Ensembl: ENSG00000168397

Variants:

dbSNP: 23192
ClinVar: 23192
TCGA: ENSG00000168397
COSMIC: ATG4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168397ENST00000344376H0Y2Y0
ENSG00000168397ENST00000400771C9JIK8
ENSG00000168397ENST00000400772F2Z2K8
ENSG00000168397ENST00000402096Q9Y4P1
ENSG00000168397ENST00000404914Q9Y4P1
ENSG00000168397ENST00000405546Q9Y4P1
ENSG00000168397ENST00000415107F2Z2K8
ENSG00000168397ENST00000419606C9J1C1
ENSG00000168397ENST00000625810F2Z2K8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379525642024FAT1 inhibits AML autophagy and proliferation via downregulating ATG4B expression.0
379525642024FAT1 inhibits AML autophagy and proliferation via downregulating ATG4B expression.0
374343642023ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1.2
377019872023Loss of ATG4B and ATG4A results in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells.0
374343642023ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1.2
377019872023Loss of ATG4B and ATG4A results in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells.0
336072582021PFKP facilitates ATG4B phosphorylation during amino acid deprivation-induced autophagy.6
337731062021ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.27
336072582021PFKP facilitates ATG4B phosphorylation during amino acid deprivation-induced autophagy.6
337731062021ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.27
318801982020The protease activity of human ATG4B is regulated by reversible oxidative modification.21
321727312020MiR-449a attenuates autophagy of T-cell lymphoma cells by downregulating ATG4B expression.7
324327422020Autophagy related 4B, upregulated by HIF-1α, attenuates the sensitivity to cisplatin in nasopharyngeal carcinoma cells.1
326859932020Differential expression and prognostic relevance of autophagy-related markers ATG4B, GABARAP, and LC3B in breast cancer.10
326868952020Distinct Mechanisms for Processing Autophagy Protein LC3-PE by RavZ and ATG4B.10

Citation

Dessen P

ATG4B (autophagy related 4B cysteine peptidase)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/672