ATG4D (autophagy related 4D cysteine peptidase)

2003-10-01  

Identity

HGNC
ATG4D
LOCATION
19p13.2
LOCUSID
84971
ALIAS
APG4-D,APG4D,AUTL4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84971
MIM: 611340
HGNC: 20789
Ensembl: ENSG00000130734

Variants:

dbSNP: 84971
ClinVar: 84971
TCGA: ENSG00000130734
COSMIC: ATG4D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130734ENST00000309469Q86TL0
ENSG00000130734ENST00000585437K7EQ67
ENSG00000130734ENST00000585752K7EKP6
ENSG00000130734ENST00000586417K7EQN3
ENSG00000130734ENST00000586477K7EP43
ENSG00000130734ENST00000586863K7EJA5
ENSG00000130734ENST00000587256K7ESM7
ENSG00000130734ENST00000588667K7EPJ0
ENSG00000130734ENST00000588857K7ERK1
ENSG00000130734ENST00000588972K7EN30
ENSG00000130734ENST00000589753K7EMB9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
337731062021ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.27
339882472021Pathogenic variants of ATG4D in infertile men with non-obstructive azoospermia identified using whole-exome sequencing.1
343138952021Silencing of ATG4D suppressed proliferation and enhanced cisplatin-induced apoptosis in hepatocellular carcinoma through Akt/Caspase-3 pathway.3
337731062021ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.27
339882472021Pathogenic variants of ATG4D in infertile men with non-obstructive azoospermia identified using whole-exome sequencing.1
343138952021Silencing of ATG4D suppressed proliferation and enhanced cisplatin-induced apoptosis in hepatocellular carcinoma through Akt/Caspase-3 pathway.3
306614292019Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.93
306614292019Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.93
303747412018The Influence of Tumor Microenvironment on ATG4D Gene Expression in Colorectal Cancer Patients.15
303747412018The Influence of Tumor Microenvironment on ATG4D Gene Expression in Colorectal Cancer Patients.15
288346902017Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma.49
288346902017Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma.49
272650292016Aberrant methylation of ATG2B, ATG4D, ATG9A and ATG9B CpG island promoter is associated with decreased mRNA expression in sporadic breast carcinoma.18
272650292016Aberrant methylation of ATG2B, ATG4D, ATG9A and ATG9B CpG island promoter is associated with decreased mRNA expression in sporadic breast carcinoma.18
235080062013Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation.52

Citation

Dessen P

ATG4D (autophagy related 4D cysteine peptidase)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/674/js/js/web-card-_common.js