PDS5B (PDS5 cohesin associated factor B)

2003-02-01  

Identity

HGNC
PDS5B
LOCATION
13q13.1
LOCUSID
23047
ALIAS
APRIN,AS3,CG008
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23047
MIM: 605333
HGNC: 20418
Ensembl: ENSG00000083642

Variants:

dbSNP: 23047
ClinVar: 23047
TCGA: ENSG00000083642
COSMIC: PDS5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000083642ENST00000315596Q9NTI5
ENSG00000083642ENST00000447833A9IYQ1
ENSG00000083642ENST00000450460Q9NTI5

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Establishment of Sister Chromatid CohesionREACTOMER-HSA-2468052
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Cohesin Loading onto ChromatinREACTOMER-HSA-2470946

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366310102023[PDS5B inhibits the proliferation of A549 human lung cancer cells via downregulation of Wnt5a].0
366310102023[PDS5B inhibits the proliferation of A549 human lung cancer cells via downregulation of Wnt5a].0
340708272021PDS5A and PDS5B in Cohesin Function and Human Disease.19
340708272021PDS5A and PDS5B in Cohesin Function and Human Disease.19
317578072020PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.28
317578072020PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.28
312338362019PDS5B regulates cell proliferation and motility via upregulation of Ptch2 in pancreatic cancer cells.7
316657412019The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination.19
312338362019PDS5B regulates cell proliferation and motility via upregulation of Ptch2 in pancreatic cancer cells.7
316657412019The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination.19
296793392018Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway.39
296793392018Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway.39
283439652017The N-Terminal Non-Kinase-Domain-Mediated Binding of Haspin to Pds5B Protects Centromeric Cohesion in Mitosis.37
283439692017Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.28
292175912017Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.349

Citation

Dessen P

PDS5B (PDS5 cohesin associated factor B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/681