MAGOH (mago homolog, exon junction complex subunit)

2014-11-01  

Identity

HGNC
MAGOH
LOCATION
1p32.3
LOCUSID
4116
ALIAS
MAGOH1,MAGOHA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4116
MIM: 602603
HGNC: 6815
Ensembl: ENSG00000162385

Variants:

dbSNP: 4116
ClinVar: 4116
TCGA: ENSG00000162385
COSMIC: MAGOH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162385ENST00000371466P61326
ENSG00000162385ENST00000371470P61326

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Exon junction complex (EJC)KEGGhsa_M00430
Exon junction complex (EJC)KEGGM00430
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382680302024MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation.0
382680302024MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation.0
373901212023MAGOH is correlated with poor prognosis and is essential for cell proliferation in lower-grade glioma.1
373901212023MAGOH is correlated with poor prognosis and is essential for cell proliferation in lower-grade glioma.1
364971172022MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases Nonsense-Mediated Decay Activity and Promotes Apoptosis via Upregulation of GADD45A.3
364971172022MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases Nonsense-Mediated Decay Activity and Promotes Apoptosis via Upregulation of GADD45A.3
308260642019The stability of Magoh and Y14 depends on their heterodimer formation and nuclear localization.4
308260642019The stability of Magoh and Y14 depends on their heterodimer formation and nuclear localization.4
293304502018C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization.8
293304502018C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization.8
239170222013Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.29
239170222013Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.29
192546942009The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.13
192546942009The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.13
169317182006Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.210

Citation

Dessen P

MAGOH (mago homolog, exon junction complex subunit)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68763