MGAM (maltase-glucoamylase)

2014-11-01  

Identity

HGNC
MGAM
LOCATION
7q34
LOCUSID
8972
ALIAS
MG,MGA

Other Information

Locus ID:

NCBI: 8972
MIM: 154360
HGNC: 7043
Ensembl: ENSG00000257335

Variants:

dbSNP: 8972
ClinVar: 8972
TCGA: ENSG00000257335
COSMIC: MGAM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000257335ENST00000465654E7EW87
ENSG00000257335ENST00000475668E7ER45
ENSG00000257335ENST00000497673E9PEQ5
ENSG00000257335ENST00000549489O43451
ENSG00000257335ENST00000620571O43451

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Galactose metabolismKEGGko00052
Starch and sucrose metabolismKEGGko00500
Galactose metabolismKEGGhsa00052
Starch and sucrose metabolismKEGGhsa00500
Metabolic pathwaysKEGGhsa01100
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Digestion of dietary carbohydrateREACTOMER-HSA-189085
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
295482572018Mechanistic Pathway on Human α-Glucosidase Maltase-Glucoamylase Unveiled by QM/MM Calculations.6
295482572018Mechanistic Pathway on Human α-Glucosidase Maltase-Glucoamylase Unveiled by QM/MM Calculations.6
257768702015A genome-wide study of inherited deletions identified two regions associated with nonsyndromic isolated oral clefts.7
257768702015A genome-wide study of inherited deletions identified two regions associated with nonsyndromic isolated oral clefts.7
250373262014Branch pattern of starch internal structure influences the glucogenesis by mucosal Nt-maltase-glucoamylase.1
250373262014Branch pattern of starch internal structure influences the glucogenesis by mucosal Nt-maltase-glucoamylase.1
234050892013Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of MGAM and ADAM9.14
234050892013Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of MGAM and ADAM9.14
225634622012Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal α-glucosidase subunit.8
225634622012Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal α-glucosidase subunit.8
220361212011Study of the inhibition of two human maltase-glucoamylases catalytic domains by different α-glucosidase inhibitors.8
220580372011Structural insight into substrate specificity of human intestinal maltase-glucoamylase.58
220361212011Study of the inhibition of two human maltase-glucoamylases catalytic domains by different α-glucosidase inhibitors.8
220580372011Structural insight into substrate specificity of human intestinal maltase-glucoamylase.58
203568442010Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.57

Citation

Dessen P

MGAM (maltase-glucoamylase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68948