MINK1 (misshapen like kinase 1)

2014-11-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
B55,MAP4K6,MINK,YSK2,ZC3
FUSION GENES

Other Information

Locus ID:

NCBI: 50488
MIM: 609426
HGNC: 17565
Ensembl: ENSG00000141503

Variants:

dbSNP: 50488
ClinVar: 50488
TCGA: ENSG00000141503
COSMIC: MINK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141503ENST00000355280Q8N4C8
ENSG00000141503ENST00000571207I3L2I2
ENSG00000141503ENST00000574453I3L4T2
ENSG00000141503ENST00000576037I3L1U1
ENSG00000141503ENST00000577021I3L203
ENSG00000141503ENST00000664602A0A590UJE1

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
387233712024MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration.0
387233712024MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration.0
359718172022The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins.3
360126582022Multi-Omic Investigations of a 17-19 Translocation Links MINK1 Disruption to Autism, Epilepsy and Osteoporosis.3
359718172022The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins.3
360126582022Multi-Omic Investigations of a 17-19 Translocation Links MINK1 Disruption to Autism, Epilepsy and Osteoporosis.3
345293192021LncRNA SNHG14 contributes to proinflammatory cytokine production in rheumatoid arthritis via the regulation of the miR-17-5p/MINK1-JNK pathway.11
345293192021LncRNA SNHG14 contributes to proinflammatory cytokine production in rheumatoid arthritis via the regulation of the miR-17-5p/MINK1-JNK pathway.11
311603822019Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics.4
311603822019Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics.4
257475782015The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71.24
257475782015The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71.24
220377662012Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.20
226654852012Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis.36
220377662012Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.20

Citation

Dessen P

MINK1 (misshapen like kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68989/img/haematological-explorer/